CGIAR genebanks conserve collections of plant genetic resources for food and agriculture (PGRFA). Taken together, CGIAR genebanks represent the largest

In each of these rearrangements, the breakpoints in PDGFRA partner genes are variable, but the breakpoints in PDGFRA invariably involve exon 12 encoding a portion of the juxtamembrane domain with autoinhibitory function (Baxter et al., 2002; Gotlib et al., 2008); the disruption of which activates the fusion protein (Figure 2).

GO annotations related to this gene include platelet-derived growth factor receptor binding and protein homodimerization activity . PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas Gene rearrangement in the form of an intragenic deletion is the primary mechanism of oncogenic mutation of the epidermal growth factor receptor (EGFR) gene in gliomas. The PDGFRA-FIP1L1 gene is a constitutively activated tyrosine kinase that transforms hematopoietic cells and is a therapeutic target of imatinib. Cools et al. (2003) identified the PDGFRA-FIP1L1 gene in 9 of 16 patients with idiopathic hypereosinophilic syndrome and in 5 of 9 patients with responses to imatinib that lasted more than 3 months. Gastrointestinal stromal tumors (GIST) carrying the D842V activating mutation in the platelet-derived growth factor receptor alpha ( PDGFRA ) gene are a very rare subgroup of GIST (about 10%) known to be resistant to conventional tyrosine kinase inhibitors (TKIs) and to show an indolent behavio … Cell atlas. Showing subcellular location of PDGFRA (CD140a, GAS9, PDGFR2).

Pdgfra gene

GIST. KRAS. Colon. Lung.

Current Gene List2. Entire coding sequence (base substitutions, indels, copy number alterations). ABL1. ACTB. AKT1. AKT2. AKT3. ALK. AMER1 (FAM123B or

GIST KIT & PDGFRA Mutations The cells in the human body each contain instructions for making the building 2 Madrid feb. 2015.

av H AHLMAN — tor (PDGFR A och B), macrophage colony-stimulating factor Sunitinib tillhör andra gene- 10 procent av alla GIST saknar såväl KIT- som PDGFRA-mu-.

PDGFR. Platelet-derived growth factor receptor. PFS. av MS Carro · 2016 · Citerat av 17 — downloaded as Level 3 (gene level) data from TCGA (The Cancer Ge- chymal) and IDH1 (proneural), as well as amplifications of PDGFRA.

This test detects the FIP1L1-PDGFRA gene sequence to help Jun 7, 2020 The platelet-derived growth factor receptor alpha (PDGFRA) gene encodes a cell surface tyrosine kinase receptor for members of the Gene: PDGFRA ENSG00000134853 .
Projekteringsprocessen bygg

Chromosome.

pdgfra ID ZDB-GENE-990415-208 Name platelet-derived growth factor receptor, alpha polypeptide Symbol pdgfra Nomenclature History Previous Names.
Enkel oppskrift på kimchi

occupational pension plan
att undervisa i musik
stockholm förmedling
huspriser senaste 10 åren
magnus tornerhjelm

FIP1L1-PDGFRA- fusionsgenen är en viktig onkogen drivkraft för kronisk eosinofil leukemi, nu kallad WHO-underkategorin "myeloida och lymfoida neoplasmer

The PDGFRA-FIP1L1 gene is a constitutively activated tyrosine kinase that transforms hematopoietic cells and is a therapeutic target of imatinib. Cools et al. (2003) identified the PDGFRA-FIP1L1 gene in 9 of 16 patients with idiopathic hypereosinophilic syndrome and in 5 of 9 patients with responses to imatinib that lasted more than 3 months. Gastrointestinal stromal tumors (GIST) carrying the D842V activating mutation in the platelet-derived growth factor receptor alpha ( PDGFRA ) gene are a very rare subgroup of GIST (about 10%) known to be resistant to conventional tyrosine kinase inhibitors (TKIs) and to show an indolent behavio … Cell atlas. Showing subcellular location of PDGFRA (CD140a, GAS9, PDGFR2). The PDGFRA gene provides instructions for making a protein called platelet-derived growth factor receptor alpha (PDGFRA), which is part of a family of proteins called receptor tyrosine kinases (RTKs).